Consider this situation. You have just downloaded a file from a little known website. And although your antivirus didnt detect anything malicious you suspect that the file may be a rogue file. And since no antivirus software has a 100% detection rate (many popular AV software have a detection rate of below 90%) it is possible that you are right. What should you do?
Thanks to web-services like Jotti’s Malware Scan and Virustotal you can now get your file scanned by multiple antivirus engines. These services allow you to upload any file and get it scanned by several antivirus softwares. Virustotal scans every file using 30 antivirus engines where as Jotti checks every file with 18 antivirus engines. However most of the time Virustotal servers are overloaded and you are made to wait in queue. If the file isnt deemed clean by all AV engines then it’s safe to assume that it is clean (unless its a 0-day exploit).